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Prolactinoma - Is it safe to take a dopamine agonist for many years?

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Both bromocriptine and cabergoline have been used for years and are generally not associated with severe complications. Recently some patients with Parkinson’s disease who have taken very high doses of cabergoline (3 mg/day) have developed fibrosis, or hardening of the heart valves. Patients with prolactinomas take substantially lower doses of cabergoline (1 to 2 mg/week) and have not been shown to have abnormalities in the heart valves.